Biofilms preserve the transmissibility of a multi-drug resistance plasmid
Abstract Self-transmissible multidrug resistance (MDR) plasmids are a major health concern because they can spread antibiotic resistance to pathogens.Even though most pathogens form biofilms, little is known about how oval endcap MDR plasmids persist and evolve in biofilms.We hypothesize that (i) biofilms act as refugia of MDR plasmids by retaining